pI: 5.5304 |
Length (AA): 511 |
MW (Da): 57833 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127036)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G39280 | probable phenylalanine--tRNA ligase alpha subunit |
Babesia bovis | BBOV_III007240 | phenylalanyl-tRNA synthetase family protein |
Brugia malayi | Bm1_08535 | phenylalanyl (f) trna synthetase protein 1 |
Candida albicans | CaO19.10477 | phenylalanyl-tRNA synthetase |
Candida albicans | CaO19.2960 | phenylalanyl-tRNA synthetase |
Caenorhabditis elegans | CELE_T08B2.9 | Protein FARS-1, isoform A |
Cryptosporidium hominis | Chro.30378 | phenylalanyl-trna synthetase-like protein |
Cryptosporidium parvum | cgd3_3320 | putative phenylalanyl-tRNA synthetase |
Chlamydia trachomatis | CT_836 | phenylalanine--tRNA ligase subunit alpha |
Dictyostelium discoideum | DDB_G0287141 | phenylalanine-tRNA ligase, alpha subunit |
Drosophila melanogaster | Dmel_CG2263 | CG2263 gene product from transcript CG2263-RA |
Escherichia coli | b1714 | phenylalanine tRNA synthetase, alpha subunit |
Echinococcus granulosus | EgrG_001147900 | phenylalanyl tRNA synthetase alpha chain B |
Entamoeba histolytica | EHI_078230 | phenylalanyl-tRNA synthetase alpha subunit, putative |
Echinococcus multilocularis | EmuJ_001147900 | phenylalanyl tRNA synthetase alpha chain B |
Giardia lamblia | GL50803_12162 | Phenylalanyl-tRNA synthetase alpha chain |
Homo sapiens | ENSG00000179115 | phenylalanyl-tRNA synthetase, alpha subunit |
Leishmania braziliensis | LbrM.32.0960 | phenylalanyl-tRNA synthetase alpha chain, putative |
Leishmania donovani | LdBPK_320920.1 | phenylalanyl-tRNA synthetase alpha chain, putative |
Leishmania infantum | LinJ.32.0920 | phenylalanyl-tRNA synthetase alpha chain, putative |
Leishmania major | LmjF.32.0870 | phenylalanyl-tRNA synthetase alpha chain, putative |
Leishmania mexicana | LmxM.31.0870 | phenylalanyl-tRNA synthetase alpha chain, putative |
Loa Loa (eye worm) | LOAG_01536 | hypothetical protein |
Mycobacterium leprae | ML1401 | Probable phenylalanyl-tRNA synthetase, alpha chain PheS |
Mus musculus | ENSMUSG00000003808 | phenylalanyl-tRNA synthetase, alpha subunit |
Mycobacterium tuberculosis | Rv1649 | Probable phenylalanyl-tRNA synthetase, alpha chain PheS |
Mycobacterium ulcerans | MUL_1635 | phenylalanyl-tRNA synthetase subunit alpha |
Neospora caninum | NCLIV_042270 | hypothetical protein |
Oryza sativa | 4348566 | Os10g0400800 |
Plasmodium berghei | PBANKA_0203800 | phenylalanine--tRNA ligase alpha subunit, putative |
Plasmodium falciparum | PF3D7_0109800 | phenylalanine--tRNA ligase alpha subunit |
Plasmodium knowlesi | PKNH_0204000 | phenylalanine--tRNA ligase alpha subunit, putative |
Plasmodium vivax | PVX_081300 | phenylalanine--tRNA ligase alpha subunit, putative |
Plasmodium yoelii | PY00417 | phenylalanyl-tRNA synthetase, putative |
Saccharomyces cerevisiae | YFL022C | phenylalanine--tRNA ligase subunit alpha |
Schistosoma japonicum | Sjp_0080790 | ko:K01889 phenylalanyl-tRNA synthetase alpha chain [EC6.1.1.20A], putative |
Schistosoma mansoni | Smp_101240 | phenylalanyl-tRNA synthetase subunit alpha |
Schmidtea mediterranea | mk4.039025.03 | |
Trypanosoma brucei gambiense | Tbg972.11.15780 | phenylalanyl-tRNA synthetase alpha chain, putative |
Trypanosoma brucei | Tb927.11.14120 | phenylalanyl-tRNA synthetase alpha chain, putative |
Trypanosoma congolense | TcIL3000.11.14420 | phenylalanyl-tRNA synthetase alpha chain, putative |
Trypanosoma cruzi | TcCLB.511727.140 | phenylalanyl-tRNA synthetase alpha chain, putative |
Toxoplasma gondii | TGME49_234505 | phenylalanyl-tRNA synthetase alpha chain A, putative |
Treponema pallidum | TP0973 | phenylalanyl-tRNA synthetase subunit alpha |
Theileria parva | TP04_0622 | phenylalanyl-tRNA synthetase alpha chain, putative |
Trichomonas vaginalis | TVAG_136640 | phenylalanyl-tRNA synthetase alpha chain, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0087 | phenylalanyl-tRNA synthetase subunit alpha |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1678 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.01.5710 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5710 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5710 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.5710 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1714 | Escherichia coli | essential | goodall |
CELE_T08B2.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T08B2.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T08B2.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T08B2.9 | Caenorhabditis elegans | sterile | wormbase |
CELE_T08B2.9 | Caenorhabditis elegans | terminal arrest variable | wormbase |
YFL022C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0203800 | Plasmodium berghei | Essential | plasmo |
TGME49_234505 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | Type-2 restriction enzyme HindIII | Compounds | References |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | Phenylalanyl-tRNA synthetase alpha chain | Compounds | References |
Streptococcus pyogenes serotype M18 (strain MGAS8232) | Phenylalanyl-tRNA synthetase alpha chain | Compounds | References |
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Phenylalanyl-tRNA synthetase alpha chain | Compounds | References |
Staphylococcus aureus | Phenylalanyl-tRNA synthetase alpha chain | Compounds | References |